Participants eligible for the AHEAD Study:

• Are healthy adults ages 55-80
• Have not been diagnosed with Alzheimer’s disease

The AHEAD Study is a four-year clinical trial evaluating a potential treatment to slow the earliest brain changes and help prevent symptoms associated with Alzheimer’s disease. The study requires a number of medical procedures that will be performed at no cost to participants, including:

• Physical examinations
• Memory and thinking tests
• Positron Emission Tomography (PET) scans (pictures of your brain taken by a device similar to an x-ray, after injecting a small dose of a detectable dye in your arm to look for the amyloid plaques and tau tangles associated with Alzheimer’s disease).
• Magnetic Resonance Imaging (MRI) scans (pictures of your brain taken by a device similar to an x-ray to assess changes in your brain structure)
• Blood and urine tests
• Once or twice-a-month intravenous (IV) infusions of an investigational treatment (or placebo) that aims to help remove amyloid plaques from the brain

The study site location is at UCSF's Memory and Aging Center located at 1651 Fourth St., Suite 212, San Francisco, CA 94158.